DLG4 antibody (N-Term)

Catalog No. ABIN372707

The Rabbit Polyclonal anti-DLG4 antibody is suitable to detect DLG4 in samples from Human, Rat, Mouse, Cow, Zebrafish (Danio rerio) and Non-Human Primate. It has been validated for WB.

Quick Overview for DLG4 antibody (N-Term) (ABIN372707)

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reactivity: Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DLG4 Antibody

Binding Specificity: N-Term

Specificity: This antibody recognizes the ~95k PSD95 protein.

Cross-Reactivity (Details): Species reactivity (expected):Human, Bovine, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat and Mouse.

Purification: Affinity Chromatography.

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of Rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Application Details

Application Notes: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C.

Target Details for DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Alternative Name: DLG4 / PSD95

Background: PSD95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).Synonyms: DLGH4, Disks large homolog 4, PSD-95, Postsynaptic density protein 95, SAP-90, SAP90, Synapse-associated protein 90

Gene ID: 29495

NCBI Accession: NP_062567

UniProt: P31016

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity