GSTM1 antibody (C-Term)

Catalog No. ABIN374509

This Goat Polyclonal antibody specifically detects GSTM1 in WB. It exhibits reactivity toward Human and Monkey.

Quick Overview for GSTM1 antibody (C-Term) (ABIN374509)

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reactivity: Human, Monkey

Host: Goat

Clonality: Polyclonal

Conjugate: This GSTM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GSTM1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to GSTM1 and will also recognise GSTM2 protein.

Purification: Affinity chromatography

Immunogen: Peptide with sequence CVFSKMAVWGNK, from the C Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/1000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Alternative Name: GSTM1

Background: Glutathione S transferases are encoded by two distinct supergene families and a total of eight distinct classes of the soluble cytoplasmic mammalian glutathione S transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of these enzymes, to which GSTM1 and 2 belong, functions in the detoxification of electrophilic compounds by conjugation with glutathione. The genes encoding the mu class of enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs and null mutations of this gene have been linked with an increase in a number of cancers.Synonyms: GST class-mu 1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, Glutathione S-transferase Mu 1

Gene ID: 2944, 9606

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity