VPS39 antibody

Catalog No. ABIN375361

Product Details anti-VPS39 Antibody

Target: VPS39 (Vacuolar Protein Sorting 39 Homolog (VPS39))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS39 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Reacts with human VPS39 102 kDa protein

Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Cross reacts with mouse and other species.

Purification: Antiserum

Immunogen: Synthetic peptide derived from an internal domain of human Vam6 protein

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/500 - WB : 1/500 to 1/2 000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

Target Details for VPS39

Target: VPS39 (Vacuolar Protein Sorting 39 Homolog (VPS39))

Alternative Name: Vam6/Vps39-Like Protein (VPS39) (VPS39 Products)

Synonyms: lbk antibody, vam6 antibody, DKFZp469J2314 antibody, A230065P22Rik antibody, AW743070 antibody, Vam6 antibody, Vam6P antibody, mVam6 antibody, TLP antibody, VAM6 antibody, hVam6p antibody, VPS39, HOPS complex subunit antibody, vacuolar protein sorting 39 homolog (S. cerevisiae) antibody, vam6/Vps39-like protein antibody, vacuolar protein sorting 39 antibody, VPS39 HOPS complex subunit antibody, VPS39 antibody, vps39 antibody, LOC100196283 antibody, NAEGRDRAFT_59276 antibody, Vps39 antibody

Background: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription.

UniProt: Q96JC1

Pathways: SARS-CoV-2 Protein Interactome