Selectin E/CD62e antibody (FITC)

Catalog No. ABIN379974

Product Details anti-Selectin E/CD62e Antibody (FITC)

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Selectin E/CD62e antibody is conjugated to FITC

Application: Please inquire

Specificity: The antigen is CD62E, the epitope has not been characterized. Antigen distribution: Isolated cells: Positive on LPS, TNFa, IL-1, or TPA stimulated endothelial cells (HUVECs) in tissue culture. No cross reactivity with other cell types known. Tissue sections: Strongly positive on human endothelial cells in acutely inflamed tissues such as atopic dermatitis or contact dermatitis 24h after sensitization, in the healthy spleen and lymph node. Few single cells express the 4D10 antigen. The antigen is generally absent in chronically inflamed tissues. Biochemistry: The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders. Specificity: Human: CD62E. Other: Not tested.

Purification: Affinity purified

Immunogen: LPS-stimulated human endothelial cells

Clone: 4D10

Application Details

Application Notes: Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS  pH 7.2, 10 mg/mL BSA, 0.1 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C.

Target Details for Selectin E/CD62e

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Alternative Name: SELE / CD62E / E-selectin (SELE Products)

Synonyms: SELE antibody, CD62E antibody, ELAM antibody, ELAM1 antibody, ESEL antibody, LECAM2 antibody, E-selectin antibody, Elam antibody, selectin E antibody, selectin, endothelial cell antibody, SELE antibody, Sele antibody

Background: Name/Gene ID: SELE

Synonyms: SELE, CD62E, ELAM, ESEL, E-selectin, LECAM2, CD62E antigen, ELAM-1, ELAM1, Selectin E

Gene ID: 6401

UniProt: P16581

Pathways: Thromboxane A2 Receptor Signaling