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c-MET antibody (Catalytic Domain)

Name: c-MET antibody (Catalytic Domain)
SKU: ABIN387741
Price: 451 USD
Availability: InStock

MET Reactivity: Human, Mouse WB, IF, IHC (p) Host: Mouse Monoclonal 4AT44 unconjugated

All lanes : Anti-MET/HGFR Antibody at dilution Lane 1: HeLa whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: COS-7 whole cell lysate Lysates/proteins at 20 μg per lane. (c-MET antibody (Catalytic Domain))

Immunohistochemical analysis of paraffin-embedded H. (c-MET antibody (Catalytic Domain))

IHC (p)

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with MET/HGFR Antibody (ABIN387741 and ABIN2837999) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (c-MET antibody (Catalytic Domain))

IHC (p)

3 images

Catalog No. ABIN387741

Datasheet as PDF

Target See all c-MET (MET) Antibodies

c-MET (MET) (Met Proto-Oncogene (MET))
Binding Specificity
41

28

27

24

12

11

8

7

7

7

5

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Catalytic Domain
Reactivity
221

128

97

5

4

4

4

4

2

2

2

1

1

1

1
Human, Mouse
Host
193

37

3

2

1
Mouse
Compatible Secondaries
Clonality
188

48
Monoclonal
Conjugate
124

18

10

10

7

7

7

7

7

7

5

5

2

2

2

2

2

2

2

2

2

2

2
This c-MET antibody is un-conjugated
Application
153

95

39

28

27

19

15

14

13

8

8

5

4

4

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen

This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met.

Clone

4AT44

Isotype

IgG1

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MET Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 5E9C4 unconjugated

anti-Met Proto-Oncogene (MET) (AA 1092-1379) antibody
MET Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) antibody
MET Reactivity: Human WB, ELISA, IHC, IF, FACS Host: Rabbit Monoclonal 2D12 unconjugated Recombinant Antibody

anti-Met Proto-Oncogene (MET) (AA 743-932) antibody
MET Reactivity: Human ELISA, FACS, ICC Host: Mouse Monoclonal 5E9B7 unconjugated

anti-Met Proto-Oncogene (MET) (C-Term) antibody
MET Reactivity: Human WB, IF, ICC, IP Host: Rabbit Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (Internal Region) antibody
MET Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (Tyr1003) antibody
MET Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 83-209) antibody
MET Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (pTyr1234) antibody
MET Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

Application Notes

IF: 1:100. WB: 1:8000. IHC-P: 1:50~100. IHC-P: 1:25

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid freeze-thaw cycles.

Storage

4 °C,-20 °C

Storage Comment

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date

6 months
Target

c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name

MET/HGFR (MET Products)

Background

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight

155541

Gene ID

4233

NCBI Accession

NP_000236, NP_001120972

UniProt

P08581

Pathways

RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor