MLLT6 antibody (C-Term)

Catalog No. ABIN2840636

Product Details anti-MLLT6 Antibody

Target: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Binding Specificity: AA 1056-1086, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLLT6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MLLT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1086 amino acids from the C-terminal region of human MLLT6.

Clone: RB2251-2252

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for MLLT6

Target: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Alternative Name: MLLT6 (MLLT6 Products)

Synonyms: AF17 antibody, MLLT6, PHD finger containing antibody, MLLT6 antibody

Background: Band 11q23 chromosome locations are associated with approximately 10 % of patients with acute lymphoblastic leukemia (ALL) and more than 5 % of patients with acute myeloid leukemia (AML). 11q23 translocation associated leukemias typically jointly express lymphoid and myeloid markers and exhibit poor prognosis. The gene at 11q23 involved in the translocations is known by multiple names, including ALL1, HRX, MLL, and TRX1. One of the more infrequent translocations, t(11,17)(q23,q21), MLLT6, encodes a protein of 1,093 amino acids, containing a leucine-zipper dimerization motif 3-prime to the fusion point and a cysteine-rich domain at the end terminus that can be arranged in 3 zinc fingers. MMLT6 contains amino acid runs associated with domains involved in transcriptional repression or activation. It has been proposed that MLLT6 represses truncated ALL1 function or inhibits function of the normal protein in leukemic cells.

Molecular Weight: 112048

Gene ID: 4302

NCBI Accession: NP_005928

UniProt: P55198