LRRK2 antibody (AA 930-961)

Catalog No. ABIN391148

The Rabbit Polyclonal anti-LRRK2 antibody has been validated for WB and IF. It is suitable to detect LRRK2 in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for LRRK2 antibody (AA 930-961) (ABIN391148)

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB07209

Product Details anti-LRRK2 Antibody

Binding Specificity: AA 930-961

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 930-961 amino acids from human PARK8(LRRK2).

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LRRK2 antibody (ABIN391148)

Huang, Song, Murphy, Holton, Lashley, Revesz, Gai, Halliday: "LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions." in: Acta neuropathologica, Vol. 116, Issue 6, pp. 639-46, (2009) (PubMed).

Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." in: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

Target Details for LRRK2

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Alternative Name: PARK8 (LRRK2)

Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Molecular Weight: 286103

Gene ID: 120892

NCBI Accession: NP_940980

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development