IMPDH2 antibody (AA 180-210)

Catalog No. ABIN391584

The Rabbit Polyclonal anti-IMPDH2 antibody (Clone RB19383) (ABIN391584) specifically detects IMPDH2 in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for IMPDH2 antibody (AA 180-210) (ABIN391584)

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IMPDH2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB19383

Product Details anti-IMPDH2 Antibody

Binding Specificity: AA 180-210

Predicted Reactivity: B, M, Rat, Ha, Zf

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for IMPDH2

Target: IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))

Alternative Name: IMPDH2

Background: IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Molecular Weight: 55805

Gene ID: 3615

NCBI Accession: NP_000875

UniProt: P12268

Pathways: Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interactome