ACVRL1 antibody (Extracellular)

Catalog No. ABIN7581966

The Rabbit Polyclonal anti-ACVRL1 antibody (ABIN7581966) specifically detects ACVRL1 in WB, FACS and LCI. The antibody is reactive with Mouse samples.

Quick Overview for ACVRL1 antibody (Extracellular) (ABIN7581966)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Product Details anti-ACVRL1 Antibody

Binding Specificity: AA 89-103, Extracellular

Purpose: A Rabbit Polyclonal Antibody to ACVRL1

Sequence: CYRSF(S)NHNVSLMLE

Specificity: Extracellular, N-terminus.

Predicted Reactivity: Mouse,rat - 14,15 identical. The antibody will not work with human samples.

Characteristics: Anti-ACVRL1 (extracellular) Antibody (ABIN7581966) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and flow cytometry applications. It has been designed to recognize ACVRL1 from mouse and rat samples. The antibody will not work with human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: CYRSF(S)NHNVSLMLE, corresponding to amino acid residues 89 - 103 of mouse ACVRL1

Isotype: IgG

Application Details

Application Notes: Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: SKR3

Background: Activin A Receptor Like Type 1, ALK1, Serine/Threonine-Protein Kinase Receptor R3, SKR3, TGF-B Superfamily Receptor Type I, TSR-I,ACVRL1, commonly known as Activin Receptor-Like Kinase 1 (ALK1), is a type I receptor in the Transforming Growth Factor-beta (TGF-β) superfamily. This receptor belongs to a family of serine/threonine kinase receptors, which form heteromeric complexes with type II receptors to transduce signals via SMAD transcription factors. ALK1 specifically interacts with Bone Morphogenetic Proteins (BMPs), particularly BMP9 and BMP10, to activate SMAD1/5/8 phosphorylation, regulating endothelial cell proliferation, maturation and migration1-5. ALK1 is primarily expressed in endothelial cells and vascular tissues, where it maintains vascular integrity. Dysregulation or mutations in ACVRL1 - the gene ALK1 - are implicated in Hereditary Hemorrhagic Telangiectasia type 2 (HHT2), which is characterized by vascular malformations and arteriovenous malformations (AVMs)2-5. Pulmonary arterial hypertension (PAH) has also been linked to ACVRL1 mutations, further emphasizing its role in vascular biology2-3. In vitro studies have shown that ALK1 promotes endothelial cell proliferation and migration, while in vivo, it prevents AVMs and supports vascular development3-5. In cancer, ALK1 signaling influences immune cell infiltration and angiogenesis, marking it as a potential therapeutic target4.

Gene ID: 11482