This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This TGF Beta Receptor I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human TGF Beta Receptor I.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze-thaw cycles.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date
6 months
Yi, Li, Nie, Jia, Zhang, Wang, Wang: "Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice." in: BMC complementary and alternative medicine, Vol. 16, pp. 222, (2017) (PubMed).
Hou, Wu, Wei, Ren, Du, Wu, Li, Shi: "CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 468, Issue 1-2, pp. 281-6, (2015) (PubMed).
Miles, Tung, Aguiar, Kurtoglu, Sikes: "Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling." in: The Prostate, Vol. 72, Issue 12, pp. 1339-50, (2012) (PubMed).
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).