PTPRE antibody (C-Term)

Catalog No. ABIN392837

Product Details anti-PTPRE Antibody

Target: PTPRE (Protein tyrosine Phosphatase, Receptor Type, E (PTPRE))

Binding Specificity: AA 558-589, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRE antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTP epsilon antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 558-589 amino acids from the C-terminal region of human PTP epsilon.

Clone: RB0551

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PTPRE antibody (ABIN392837)

Zheng, Resnick, Shalloway: "Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi." in: International journal of cancer, Vol. 122, Issue 9, pp. 1999-2007, (2008) (PubMed).

Target Details for PTPRE

Target: PTPRE (Protein tyrosine Phosphatase, Receptor Type, E (PTPRE))

Alternative Name: PTP epsilon (PTPRE Products)

Synonyms: ptpra antibody, HPTPE antibody, PTPE antibody, R-PTP-EPSILON antibody, PTPe antibody, PTPepsilon antibody, RPTPepsilon antibody, protein tyrosine phosphatase, receptor type E L homeolog antibody, protein tyrosine phosphatase, receptor type E antibody, protein tyrosine phosphatase, receptor type, E antibody, ptpre.L antibody, PTPRE antibody, Ptpre antibody

Background: PTPepsilon is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of the gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.

Molecular Weight: 80642

Gene ID: 5791

NCBI Accession: NP_006495, NP_569119

UniProt: P23469