TBK1 antibody (AA 563-577)

Catalog No. ABIN400648

This Mouse Monoclonal antibody specifically detects TBK1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse, Rat, Cow and Dog.

Quick Overview for TBK1 antibody (AA 563-577) (ABIN400648)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 108A429

Product Details anti-TBK1 Antibody

Binding Specificity: AA 563-577

Specificity: This antibody recognizes Human TANK-Binding Kinase 1 (TBK1/NAK).

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human.

Characteristics: Synonyms: NAK, TANK-binding kinase 1, T2K, NF-kappa-B-activating kinase

Purification: Protein G Chromatography

Immunogen: A synthetic peptide corresponding to amino acids 563-577 of Human TBK1 - KLHconjugated. AA Sequence: YYQFKKDKAERRLAYCRemarks: This sequence is 100% conserved between Human, Mouse, Rat, Dog and Cow.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, 0.05 % Sodium Azide, 0.2 % Gelatin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: TBK1

Background: NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor-associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family. Similar to IKK alpha and beta, NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536. NAK is also known to interact with TANK, TRAF-2 and TRIF.Synonyms: NAK, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1

Gene ID: 29110

UniProt: Q9UHD2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome