SMPD3 antibody

Catalog No. ABIN4620370

The Rabbit Polyclonal anti-SMPD3 antibody is suitable to detect SMPD3 in samples from Human. It has been validated for WB.

Quick Overview for SMPD3 antibody (ABIN4620370)

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMPD3 Antibody

Specificity: This antibody detects Sphingomyelin Phosphodiesterase 3, predominantly expressed in the brain.

Purification: Affinity chromatography

Immunogen: Synthetic peptide derived from human sphingomyelin phosphodiesterase 3

Application Details

Application Notes: Western blot (1: 400 starting dilution). Protein appears to run lower than expected proteinmolecular weight. However, antibody is specific for the protein and band blocks whenblocking peptide used.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Alternative Name: SMPD3

Background: Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.Synonyms: Neutral sphingomyelinase 2, Neutral sphingomyelinase II, Sphingomyelin phosphodiesterase 3

Gene ID: 55512

NCBI Accession: NP_061137

UniProt: Q9NY59

Pathways: Hormone Transport