Integrin beta 2 antibody (FITC)

Catalog No. ABIN4880066

This anti-Integrin beta 2 antibody is a Mouse Monoclonal antibody detecting Integrin beta 2 in FACS, IF and ICC. Suitable for Human.

Quick Overview for Integrin beta 2 antibody (FITC) (ABIN4880066)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 24

Product Details anti-Integrin beta 2 Antibody (FITC)

Specificity: This antibody recognises integrin alpha L,M,X/Beta 2 (CD11/CD18). Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1) with integrin alpha M (CD11b) to form Complement Receptor 3 (CR3) and with integrin alpha X (CD11c) to form Complement Receptor 4 (CR4). Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs). Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Purification: Purified on protein A from tissue culture supernatant.

Immunogen: Fibronectin-purified human monocytes

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration

Comment:

Myeloma, fusion partners: Cells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: Purified IgG conjugated to Fluoroscein using Innova Biosciences Lightning-Link®, supplied in Phosphate buffered saline (PBS) containing 0.09 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: CD11/CD18

Gene ID: 3683, 3684, 3687

UniProt: P05107, P11215, P20701

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation