CDK6 antibody

Catalog No. ABIN488121

The Mouse Monoclonal anti-CDK6 antibody (Clone DCS-83) (ABIN488121) specifically detects CDK6 in WB and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CDK6 antibody (ABIN488121)

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDK6 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: DCS-83

Product Details anti-CDK6 Antibody

Specificity: This antibody reacts with Cdk6.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse and Rat.

Purification: Protein-A Sepharose Chromatography.

Immunogen: Recombinant Cdk6 protein. Remarks: Hybridoma was established by fusion of mouse myeloma cell NS-2 with Balb/c mouse splenocyte.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Target Details for CDK6

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Alternative Name: CDK6

Background: Cdk6 (Cyclin-dependent kinase-6) is a 38-40 kDa member of the Cdk family of mitotic kinases involved in cell cycle progression. The Cdk6 phosphoprotein, like Cdk4, associates with D-cyclins to regulate cell proliferation. Following translocation to the nucleus, the Cdk6 is phosphorylated by CAK, and the Cdk6 complex, in association with PCNA, phosphorylates the retinoblastoma (Rb) protein. Overexpression of Cdk6 has been associated with several different types of cancer.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE

Gene ID: 1021

NCBI Accession: NP_001250

UniProt: Q00534

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases