Complement Factor B antibody (AA 518-764)
-
- Target See all Complement Factor B (CFB) Antibodies
- Complement Factor B (CFB)
-
Binding Specificity
- AA 518-764
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Complement Factor B antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Rabbit IgG polyclonal antibody for Complement factor B(CFB) detection. Tested with WB, IHC-P in Human.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
-
Rabbit IgG polyclonal antibody for Complement factor B(CFB) detection. Tested with WB, IHC-P in Human.
Gene Name: complement factor B
Protein Name: Complement factor B - Purification
- Immunogen affinity purified.
- Immunogen
- E. coli-derived human Factor B recombinant protein (Position: E518-L764). Human Factor B shares 84.2% amino acid (aa) sequence identity with mouse Factor B.
- Isotype
- IgG
- Top Product
- Discover our top product CFB Primary Antibody
-
-
- Application Notes
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
-
- Target
- Complement Factor B (CFB)
- Alternative Name
- CFB (CFB Products)
- Synonyms
- AHUS4 antibody, BF antibody, BFD antibody, CFAB antibody, FB antibody, FBI12 antibody, GBG antibody, H2-Bf antibody, PBF2 antibody, bf antibody, Bf-1 antibody, Brre-Bf antibody, zgc:114032 antibody, Bf antibody, Sp152 antibody, bfb-A antibody, Bf B antibody, LOC397725 antibody, bf/c2 antibody, CFB antibody, AI195813 antibody, AI255840 antibody, B antibody, C2 antibody, Fb antibody, Da1-24 antibody, complement factor B antibody, complement factor B S homeolog antibody, complement factor B L homeolog antibody, CFB antibody, cfb antibody, bf antibody, cfb.S antibody, cfb.L antibody, bf/c2 antibody, LOC100555981 antibody, Cfb antibody
- Background
-
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Synonyms: AHUS4 | B factor properdin | BF | BFD | C3 proaccelerator | C3 proactivator | CFAB | CFB | Complement Factor B | FB | FBI12 | GBG | Glycine rich beta glycoprotein | H2 Bf | H2BF | PBF2 | Properdin factor B | P00751 - Gene ID
- 629
- UniProt
- P00751
- Pathways
- Complement System, Proton Transport, Ribonucleoside Biosynthetic Process
-