Histone H4 (2meLys20) antibody

Details for Product No. ABIN4889660, Supplier: Log in to see
Antigen
  • hist1h4l
  • H1ft
  • Hist4
  • Hist4h4
  • H4
  • X04652
  • FO108
  • H4/n
  • H4F2
  • H4FN
  • HIST2H4
  • H4C13
  • H4C7
  • F8N16.2
  • F8N16_2
  • histone H4
  • BcDNA:RH52884
  • CG3379
  • Dmel\CG3379
  • H4r
  • His4-88CD
  • His4R
  • histone cluster 1, H4a L homeolog
  • histone cluster 1 H4 family member B
  • histone cluster 2, H4
  • histone cluster 2 H4 family member a
  • histone H4
  • Histone H4 replacement
  • Histone H4
  • hist1h4a.L
  • Hist1h4b
  • Hist2h4
  • HIST2H4A
  • H4
  • H4C14
  • HIS4
  • HIST2H4
  • His4r
  • his-38
Epitope
2meLys20
81
73
66
62
54
53
32
29
25
22
17
15
15
15
13
12
9
8
8
7
7
6
6
6
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
693
506
426
83
40
37
36
36
35
28
28
27
13
11
9
9
8
4
4
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
Host
Mouse
631
106
6
3
Clonality
Monoclonal
Conjugate
Un-conjugated
17
17
16
14
13
10
9
9
9
9
9
5
5
5
5
5
5
5
5
5
4
4
4
3
2
2
2
2
Application
Western Blotting (WB)
621
324
227
227
205
126
113
108
100
65
32
22
11
10
9
7
6
3
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This Histone H4 dimethylLys20 antibody was raised against a peptide including dimethylLys20 of human histone H4.
Isotype IgG
Purification Culture Supernatant
Antigen
Background Histone H4 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post- translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, these modifications play a major role in regulating gene expression. Histone 4 lysine 20 (H4K20) can be mono-, di- or trimethylated by different histone methyltransferases such as NSD1 or ASH1. The methylation of this lysine is often associated with transcriptional repression.
Molecular Weight 8 kDa
Gene ID 121504
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer Concentrated culture supernatant containing 30 % glycerol and 0.035 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage -20 °C
Storage Comment Antibodies in solution can be stored at -20 °C for 2 years.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Histone H4 (2meLys20) antibody (ABIN4889660) Histone H4 dimethyl Lys20 mAb tested by Western blot. Detection of dimethylated Histo...
Product cited in: Li, Corsa, Pan, Wu, Ferguson, Yu, Min, Dou: "MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1." in: Molecular and cellular biology, Vol. 30, Issue 22, pp. 5335-47, 2010 (PubMed).

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