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- Target
- CD17
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Flow Cytometry (FACS)
- Specificity
- The mouse monoclonal antibody MEM-68 recognizes CD17, an extracellular membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Pre-B cell line NALM-6
- Clone
- MEM-68
- Isotype
- IgM
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-
- Application Notes
- Flow cytometry: Recommended dilution: 2 μg/mL.
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
-
- Target
- CD17
- Background
- CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.,Lactosylceramide
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