Beclin 1 antibody (AA 110-190)
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- Target See all Beclin 1 (BECN1) Antibodies
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
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Binding Specificity
- AA 110-190
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Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Beclin 1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Beclin-1 is a protein encoded by the ECN1 gene which is approximately 51,9 kDa. Beclin-1 is localised to the cytoplasm, Golgi apparatus and mitochondrion membrane. It is involved in the autophagy pathway, deubiquitination, metabolism of proteins, apelin signalling pathway and nanomaterial induced apoptosis. The beclin-1 protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which plays a role in multiple membrane trafficking pathways. PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. It also plays a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Beclin-1 is ubiquitously expressed. Mutations in the ECN1 gene can result in cervical cancer, breast cancer and Wolfram syndrome. STJ97761 was affinity-purified from rabbit. This antibody detects endogenous beclin-1.
- Specificity
- Beclin-1 Mouse Monoclonal Antibody (5C2) detects endogenous levels of BECN1
- Characteristics
- Mouse Monoclonal to Beclin-1.
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Immunogen
- synthetic peptide derived from Beclin-1
- Clone
- 5C2
- Isotype
- IgG1
- Top Product
- Discover our top product BECN1 Primary Antibody
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- Application Notes
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WB 1:1000-2000
IHC 1:100-200 - Comment
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Ubiquitous.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
- Alternative Name
- Beclin-1 (BECN1 Products)
- Synonyms
- beclin-1 antibody, atg6 antibody, vps30 antibody, beclin1 antibody, Beclin-1 antibody, becn1 antibody, zgc:73097 antibody, ATG6 antibody, VPS30 antibody, 4921513J16Rik antibody, 5430417M23Rik antibody, Atg6 antibody, beclin 1 antibody, beclin 1, autophagy related antibody, beclin 1 protein antibody, beclin-1 antibody, beclin family protein antibody, beclin 1, autophagy related L homeolog antibody, BECN1 antibody, becn1 antibody, atg6 antibody, CpipJ_CPIJ011087 antibody, PTRG_07825 antibody, SJAG_01876 antibody, Becn1 antibody, becn1.L antibody
- Gene ID
- 8678
- UniProt
- Q14457
- Pathways
- Autophagy
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