Lamin A/C antibody

Catalog No. ABIN4901871

This anti-Lamin A/C antibody is a Mouse Monoclonal antibody detecting Lamin A/C in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Lamin A/C antibody (ABIN4901871)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4E7

Product Details anti-Lamin A/C Antibody

Purpose: Mouse monoclonal to Lamin A.

Specificity: Lamin A Monoclonal Antibody detects endogenous levels of Lamin A protein.

Characteristics: Mouse Monoclonal to Lamin A.

Purification: Affinity purification

Immunogen: Purified recombinant fragment of human Lamin A expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000

Comment:

In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.

Restrictions: For Research Use only

Handling

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus