COPS3 antibody (AA 261-360)

Catalog No. ABIN4908217

Product Details anti-COPS3 Antibody

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Binding Specificity: AA 261-360

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS3

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Alternative Name: COPS3 (COPS3 Products)

Synonyms: CG18332 antibody, CH3 antibody, Csn3 antibody, DCH3 antibody, Dch3 antibody, Dmel\\CG18332 antibody, FBgn0027055 antibody, dCSN3 antibody, COPS3 antibody, CSN3 antibody, DKFZp468P1922 antibody, Sgn3 antibody, wu:fc32a02 antibody, wu:fk59f01 antibody, zgc:111903 antibody, zgc:55643 antibody, zgc:77615 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 13 antibody, COP9 SIGNALOSOME SUBUNIT 3 antibody, F18O22.40 antibody, F18O22_40 antibody, FUS11 antibody, FUSCA 11 antibody, SGN3 antibody, csn3 antibody, COP9 signalosome subunit 3 antibody, Proteasome component (PCI) domain protein antibody, COP9 signalosome subunit 3 L homeolog antibody, COP9 signalosome complex subunit 3 antibody, CSN3 antibody, cops3 antibody, COPS3 antibody, Cops3 antibody, COP13 antibody, cops3.L antibody, csn-3 antibody

Background:

Synonyms: COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene ID: 8533

Pathways: Cell Division Cycle