p63 antibody

Catalog No. ABIN4914776

Product Details anti-p63 Antibody

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This p63 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.

Clone: 3C3

Isotype: IgM

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: TP63 (TP63 Products)

Synonyms: AIS antibody, B(p51A) antibody, B(p51B) antibody, EEC3 antibody, KET antibody, LMS antibody, NBP antibody, OFC8 antibody, RHS antibody, SHFM4 antibody, TP53CP antibody, TP53L antibody, TP73L antibody, p40 antibody, p51 antibody, p53CP antibody, p63 antibody, p73H antibody, p73L antibody, TP63 antibody, tp63 antibody, DNp63 antibody, id:ibd3516 antibody, tp73l antibody, wu:fc89f04 antibody, wu:fk85h07 antibody, wu:fk88b02 antibody, Ket antibody, P73l antibody, Tp73l antibody, Trp63 antibody, TRP63 antibody, AI462811 antibody, P51/P63 antibody, P63 antibody, Tp63 antibody, Trp53rp1 antibody, Xp63 antibody, ket antibody, np63 antibody, tp73l-A antibody, trp63 antibody, tumor protein p63 antibody, transformation related protein 63 antibody, tumor protein p63 L homeolog antibody, TP63 antibody, tp63 antibody, Tp63 antibody, Trp63 antibody, tp63.L antibody

Background:

Synonyms: AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), Tumor protein 63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like

Background: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Gene ID: 8626

UniProt: Q9H3D4