TRAF2 antibody
-
- Target See all TRAF2 Antibodies
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This TRAF2 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Immunogen
- This TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.
- Clone
- 4C4
- Isotype
- IgG1
- Top Product
- Discover our top product TRAF2 Primary Antibody
-
-
- Application Notes
-
WB 1:300-5000
IF() - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
-
- Target
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
- Alternative Name
- TRAF2 (TRAF2 Products)
- Synonyms
- MGC:45012 antibody, TRAP antibody, TRAP3 antibody, TANK antibody, AI325259 antibody, TNF-receptor-associated factor 2 antibody, conjugal transfer protein TraF antibody, TNF receptor associated factor 2 antibody, TNF receptor-associated factor 2 antibody, Tnf receptor-associated factor 2 antibody, LOC661716 antibody, traF2 antibody, TRAF2 antibody, Traf2 antibody
- Background
-
Synonyms: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3, TRAF2
Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
- Gene ID
- 7186
- UniProt
- Q12933
- Pathways
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins
-