CD4 antibody (N-Term)

Catalog No. ABIN492544

This Mouse Monoclonal antibody specifically detects CD4 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CD4 antibody (N-Term) (ABIN492544)

Target: CD4

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 8G1B12

Product Details anti-CD4 Antibody

Binding Specificity: N-Term

Specificity: Recognizes CD4

Characteristics: Synonyms: T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3

Purification: Immunoaffinity Chromatography.

Immunogen: A 193 amino acid recombinant protein from near the amino terminus of Human CD4(GenBank accession No. NP_000607)

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CD4 antibody can be used for detection of CD4 at 0.5-1 μg/mL. Positive Control: Rat Lung Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD4

Target: CD4

Alternative Name: CD4

Background: CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 Molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4

Gene ID: 920

UniProt: P01730

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events