CFTR / Cystic Fibrosis Transmembrane Regulator (AA 258-385) antibody

Catalog No. ABIN4949563

The Mouse Monoclonal anti- antibody has been validated for IHC (p) and IF. It is suitable to detect in samples from Human.

Quick Overview for CFTR / Cystic Fibrosis Transmembrane Regulator (AA 258-385) antibody (ABIN4949563)

Target: CFTR / Cystic Fibrosis Transmembrane Regulator

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: CFTR-1643

Product Details

Binding Specificity: AA 258-385

Purification: Protein G affinity chromatography

Immunogen: A partial recombinant protein corresponding to amino acids 258-385 from the human protein was used as the immunogen for this CFTR antibody.

Isotype: IgG2b

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.\. IF: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the CFTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details

Target: CFTR / Cystic Fibrosis Transmembrane Regulator

Background: Cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. [UniProt]

Gene ID: 1080