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CFTR / Cystic Fibrosis Transmembrane Regulator (AA 258-385) antibody

Reactivity: Human IHC (p), IF Host: Mouse Monoclonal CFTR-1643 unconjugated
Catalog No. ABIN4949564
  • Target
    CFTR / Cystic Fibrosis Transmembrane Regulator
    Binding Specificity
    AA 258-385
    Reactivity
    • 9
    • 4
    Human
    Host
    • 5
    • 4
    Mouse
    Clonality
    • 9
    Monoclonal
    Conjugate
    • 9
    Un-conjugated
    Application
    • 9
    • 7
    • 4
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    Protein G affinity chromatography
    Immunogen
    A partial recombinant protein corresponding to amino acids 258-385 from the human protein was used as the immunogen for this CFTR antibody.
    Clone
    CFTR-1643
    Isotype
    IgG2b
  • Application Notes
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.\. IF: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Preservative
    Azide free
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the CFTR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    CFTR / Cystic Fibrosis Transmembrane Regulator
    Background
    Cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. [UniProt]
    Gene ID
    1080
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