JUP antibody (full length, N-Term)

Catalog No. ABIN4949714

The Mouse Monoclonal anti-JUP antibody (Clone 11E4-) (ABIN4949714) specifically detects JUP in WB, IF and FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for JUP antibody (full length, N-Term) (ABIN4949714)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: 11E4-

Product Details anti-JUP Antibody

Binding Specificity: full length, N-Term

Purpose: Plakoglobin Antibody / Gamma Catenin (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Isotype: IgG1, kappa

Application Details

Application Notes: Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: Plakoglobin

Background: It recognizes a protein of 80-87 kDa, identified as gamma-Catenin or Plakoglobin. The catenins (i±, i², i³ and i´) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. i± T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. i± T-catenin binds to i± E-catenin as well as to i²-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for i±-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location