TSHR, A Chain antibody

Catalog No. ABIN4949908

Product Details anti-TSHR, A Chain Antibody

Target: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TSHR, A Chain antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogen: Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.

Clone: TSHRA-1402

Isotype: IgG

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSHR antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the TSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for TSHR, A Chain

Target: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Alternative Name: Thyroid Stimulating Hormone Receptor / TSHR (alpha chain) (TSHR, A Chain Products)

Background: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.