CHEK1 antibody (AA 258-287)

Catalog No. ABIN3030468

This anti-CHEK1 antibody is a Rabbit Polyclonal antibody detecting CHEK1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for CHEK1 antibody (AA 258-287) (ABIN3030468)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHEK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHEK1 Antibody

Binding Specificity: AA 258-287

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 258-287 from the human protein was used as the immunogen for this CHK1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CHK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C for up to one month. For long term, aliquot the CHK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name: CHK1

Background: Checkpoint kinase 1, commonly referred to as CHK1 is an serine/threonine-specific protein kinase that in humans, is encoded by the CHEK1 gene. CHK1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.

UniProt: O14757

Pathways: p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair