APP antibody (AA 735-763)

Catalog No. ABIN3029685

The Rabbit Polyclonal anti-APP antibody (ABIN3029685) specifically detects APP in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for APP antibody (AA 735-763) (ABIN3029685)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APP Antibody

Binding Specificity: AA 735-763

Purpose: Amyloid beta Precusor Protein Antibody

Cross-Reactivity (Details): Expected species reactivity: Mouse, Pig, Primate, Rat

Purification: Antigen affinity

Immunogen: A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Amyloid beta precusor protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Amyloid beta precusor protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: Amyloid beta Precusor Protein

Background: APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour