Androgen Receptor antibody (AA 475-504)

Catalog No. ABIN3029943

This anti-Androgen Receptor antibody is a Rabbit Polyclonal antibody detecting Androgen Receptor in WB and ELISA. Suitable for Human.

Quick Overview for Androgen Receptor antibody (AA 475-504) (ABIN3029943)

Target: Androgen Receptor (AR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Androgen Receptor Antibody

Binding Specificity: AA 475-504

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 475-504 from the human protein was used as the immunogen for this AR antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: AR

Background: The androgen receptor, also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. It is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.
The main function of the AR is as a DNA-binding transcription factor that regulates gene expression, however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. [Wiki]

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding