BAX antibody (AA 47-78)
Quick Overview for BAX antibody (AA 47-78) (ABIN3030141)
Target
See all BAX AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 47-78
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Purification
- Antigen affinity purified
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Immunogen
- This BAX antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 47-78 amino acids from the N-terminal region of human BAX.
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Isotype
- Ig Fraction
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Application Notes
- Titration of the BAX antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the BAX antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- BAX (BCL2-Associated X Protein (BAX))
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Alternative Name
- BAX
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Background
- Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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UniProt
- Q07812
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Pathways
- p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
Target
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