CD46 antibody (AA 330-361)

Catalog No. ABIN3030406

This Rabbit Polyclonal antibody specifically detects CD46 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for CD46 antibody (AA 330-361) (ABIN3030406)

Target: CD46

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD46 Antibody

Binding Specificity: AA 330-361

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 330-361 from the human protein was used as the immunogen for this CD46 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CD46 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD46 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization