MAP3K12 antibody

Catalog No. ABIN3031847

The Rabbit Polyclonal anti-MAP3K12 antibody has been validated for ELISA, WB and IHC. It is suitable to detect MAP3K12 in samples from Human.

Quick Overview for MAP3K12 antibody (ABIN3031847)

Target: MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K12 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MAP3K12 Antibody

Purification: Antigen affinity purified

Immunogen: This DLK antibody was produced from rabbits immunized with a recombinant protein of human DLK.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DLK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DLK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MAP3K12

Target: MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))

Alternative Name: DLK

Background: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes, it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance, this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

UniProt: P80370

Pathways: MAPK Signaling