FGFR1 antibody (AA 441-470)

Catalog No. ABIN3029718

The Rabbit Polyclonal anti-FGFR1 antibody (ABIN3029718) specifically detects FGFR1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for FGFR1 antibody (AA 441-470) (ABIN3029718)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FGFR1 Antibody

Binding Specificity: AA 441-470

Purpose: FGFR Antibody

Cross-Reactivity (Details): Expected species reactivity: Chicken, Mouse, Rat

Purification: Antigen affinity

Immunogen: A portion of amino acids 441-470 from the human protein was used as the immunogen for this FGFR antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the FGFR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FGFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Background: FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.

UniProt: P11362

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins