Integrin beta 2 antibody

Catalog No. ABIN3031375

This Rabbit Polyclonal antibody specifically detects Integrin beta 2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Integrin beta 2 antibody (ABIN3031375)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Integrin beta 2 Antibody

Purification: Antigen affinity purified

Immunogen: This Integrin beta 2 antibody was produced from rabbits immunized with a recombinant protein from the human ITGB2.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Integrin beta 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: Integrin beta 2

Background: The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation