MIB1 antibody (AA 13-42)

Catalog No. ABIN3031774

This Rabbit Polyclonal antibody specifically detects MIB1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for MIB1 antibody (AA 13-42) (ABIN3031774)

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MIB1 Antibody

Binding Specificity: AA 13-42

Purpose: Mib1 Antibody

Cross-Reactivity (Details): Expected species reactivity: Mouse, Zebrafish, Xenopus

Purification: Purified

Immunogen: A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Mib1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MIB1

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Alternative Name: Mib1

Background: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection