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MIB1 antibody (AA 13-42)

MIB1 Reactivity: Human IF, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031774
$578.58
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  • Target See all MIB1 Antibodies
    MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
    Binding Specificity
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 13-42
    Reactivity
    • 36
    • 20
    • 11
    • 5
    • 2
    • 1
    Human
    Host
    • 40
    • 2
    Rabbit
    Clonality
    • 32
    • 10
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    This MIB1 antibody is un-conjugated
    Application
    • 18
    • 16
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Zebrafish, Xenopus
    Purification
    Purified
    Immunogen
    A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:20-1:100,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the Mib1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
    Alternative Name
    Mib1 (Mindbomb) (MIB1 Products)
    Synonyms
    DIP-1 antibody, DIP1 antibody, LVNC7 antibody, MIB antibody, ZZANK2 antibody, ZZZ6 antibody, E430019M12Rik antibody, Mib antibody, mKIAA1323 antibody, dip-1 antibody, mib antibody, mindbomb antibody, cg5841 antibody, chunp6889 antibody, fe47f05 antibody, im:7148100 antibody, mib1 antibody, wu:fe47f05 antibody, CG5841 antibody, D-mib antibody, D-mib1 antibody, Dmel\CG5841 antibody, Dmib antibody, MIB1 antibody, Mib1 antibody, dmib1 antibody, l(3)72CDa antibody, l(3)72Db antibody, mib1/2 antibody, mind-bomb antibody, mindbomb E3 ubiquitin protein ligase 1 antibody, mindbomb E3 ubiquitin protein ligase 1 L homeolog antibody, mind bomb 1 antibody, MIB1 antibody, Mib1 antibody, mib1.L antibody, mib1 antibody
    Background
    MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
    UniProt
    Q86YT6
    Pathways
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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