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MYLK3 antibody (AA 40-69)

MYLK3 Reactivity: Human, Mouse IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031919
$578.58
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  • Target See all MYLK3 Antibodies
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Binding Specificity
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-69
    Reactivity
    • 54
    • 37
    • 18
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 65
    Rabbit
    Clonality
    • 65
    Polyclonal
    Conjugate
    • 18
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYLK3 antibody is un-conjugated
    Application
    • 42
    • 34
    • 28
    • 12
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    A portion of amino acids 40-69 from the human protein was used as the immunogen for this MYLK3 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the MYLK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the MYLK3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Alternative Name
    MYLK3 (MYLK3 Products)
    Synonyms
    MLCK antibody, MLCK2 antibody, caMLCK antibody, D830007F02Rik antibody, RGD1305801 antibody, myosin light chain kinase 3 antibody, MYLK3 antibody, Mylk3 antibody
    Background
    MLCK/MYLK3, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.
    UniProt
    Q32MK0
    Pathways
    Regulation of Muscle Cell Differentiation
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