NKX3-1 antibody (AA 3-1)

Catalog No. ABIN3032012

The Rabbit Polyclonal anti-NKX3-1 antibody is suitable to detect NKX3-1 in samples from Mouse. It has been validated for WB and ELISA.

Quick Overview for NKX3-1 antibody (AA 3-1) (ABIN3032012)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NKX3-1 Antibody

Binding Specificity: AA 3-1

Purpose: Nkx3.1 Antibody

Purification: Antigen affinity

Immunogen: A portion of amino acids 3-1 from the mouse protein was used as the immunogen for this Nkx3.1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Nkx3.1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Nkx3.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: Nkx3.1

Background: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Play a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland.

UniProt: P97436

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus