NOTCH4 antibody (C-Term)

Catalog No. ABIN3032033

The Rabbit Polyclonal anti-NOTCH4 antibody is suitable to detect NOTCH4 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for NOTCH4 antibody (C-Term) (ABIN3032033)

Target: NOTCH4 (Notch 4 (NOTCH4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NOTCH4 Antibody

Binding Specificity: AA 1819-1851, C-Term

Purpose: NOTCH4 Antibody

Purification: Antigen affinity

Immunogen: This NOTCH4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1819-1851 amino acids from the C-terminal region of human NOTCH4.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the NOTCH4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the NOTCH4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NOTCH4

Target: NOTCH4 (Notch 4 (NOTCH4))

Alternative Name: NOTCH4

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

UniProt: Q99466

Pathways: Notch Signaling