Tuberin antibody (pSer939)

Catalog No. ABIN3029774

The Rabbit Polyclonal anti-Tuberin antibody has been validated for ELISA, DB and IF. It is suitable to detect Tuberin in samples from Human.

Quick Overview for Tuberin antibody (pSer939) (ABIN3029774)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tuberin antibody is un-conjugated

Application: ELISA, Dot Blot (DB), Immunofluorescence (IF)

Product Details anti-Tuberin Antibody

Binding Specificity: pSer939

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity purified

Immunogen: This p-Tuberin antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS939 of human TSC2.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the p-Tuberin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the p-Tuberin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Alternative Name: Tuberin

Background: Mutations in TSC2/Tuberin lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

UniProt: P49815

Pathways: RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus