KIT antibody (pTyr578)

Catalog No. ABIN3031699

This Rabbit Polyclonal antibody specifically detects KIT in ELISA and DB. It exhibits reactivity toward Human.

Quick Overview for KIT antibody (pTyr578) (ABIN3031699)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIT antibody is un-conjugated

Application: ELISA, Dot Blot (DB)

Product Details anti-KIT Antibody

Binding Specificity: pTyr578

Cross-Reactivity (Details): Expected species reactivity: Bovine, Chicken, Mouse, Pig

Purification: Antigen affinity purified

Immunogen: This phospho-c-Kit antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY578 of human c-Kit.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-c-Kit antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-c-Kit antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Alternative Name: C-Kit

Background: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P10721

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity