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TBK1 antibody (AA 8-35)
TBK1
Reactivity: Mouse
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TBK1 Antibody
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Target
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TBK1
(TANK-Binding Kinase 1 (TBK1))
Binding Specificity
All epitopes for TBK1 antibodies
AA 8-35
Reactivity
All reactivities for TBK1 antibodies
Mouse
Host
All hosts for TBK1 antibodies
Rabbit
Clonality
All clonalities for TBK1 antibodies
Polyclonal
Conjugate
All conjugates for TBK1 antibodies
This TBK1 antibody is un-conjugated
Application
All applications for TBK1 antibodies
Western Blotting (WB), ELISA
Purification
Antigen affinity purified
Immunogen
A portion of amino acids 8-35 from the mouse protein was used as the immunogen for this Tbk1 antibody.
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Titration of the Tbk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the Tbk1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for TBK1
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Target
TBK1
(TANK-Binding Kinase 1 (TBK1))
Alternative Name
Tbk1 (TBK1 Products )
Synonyms
nak antibody, t2k antibody, TBK1 antibody, wu:fk70c05 antibody, zgc:136548 antibody, NAK antibody, T2K antibody, 1200008B05Rik antibody, AI462036 antibody, AW048562 antibody, TANK binding kinase 1 L homeolog antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, tbk1.L antibody, TBK1 antibody, tbk1 antibody, Tbk1 antibody
Background
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
UniProt
Q9WUN2
Pathways
TLR Signaling , Activation of Innate immune Response , Hepatitis C , Toll-Like Receptors Cascades , SARS-CoV-2 Protein Interactome
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