Adracalin antibody (AA 51-150) (Alexa Fluor 750)

Catalog No. ABIN4996152

Product Details anti-Adracalin Antibody (Alexa Fluor 750)

Target: Adracalin (AAAS) (Achalasia, Adrenocortical Insufficiency, Alacrimia (AAAS))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adracalin antibody is conjugated to Alexa Fluor 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Adracalin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Adracalin

Target: Adracalin (AAAS) (Achalasia, Adrenocortical Insufficiency, Alacrimia (AAAS))

Alternative Name: Adracalin (AAAS Products)

Synonyms: zgc:85873 antibody, aladin antibody, Aladin antibody, AAA antibody, AAASb antibody, ADRACALA antibody, ADRACALIN antibody, ALADIN antibody, D030041N15Rik antibody, GL003 antibody, aladin WD repeat nucleoporin antibody, achalasia, adrenocortical insufficiency, alacrimia antibody, aladin WD repeat nucleoporin L homeolog antibody, Aaas antibody, aaas antibody, aaas.L antibody, AAAS antibody

Background:

Synonyms: AAA, AAAS, AAASb, Achalasia adrenocortical insufficiency alacrimia Allgrove triple A, Achalasia adrenocortical insufficiency alacrimia, ADRACALA, Aladin, Allgrove triple A, DKFZp586G1624, GL003, AAAS_HUMAN.

Background: Aladin (Adracalin) belongs to a family of WD repeat-containing proteins. These proteins have a wide variety of functions, including signal transduction regulation, RNA processing and transcription. Aladin plays a role in peripheral and central nervous system development. It is widely expressed, with the highest expression seen in pituitary gland, corpus callosum, cerebellum, adrenal gland and gastrointestinal structures. Defects in Aladin cause the autosomal recessive disorder achalasia-addisonianism-alacrima (triple A) syndrome. Triple A syndrome is characterized by achalasia, alacrima and adrenocortico-tropin-resistant adrenal insufficiency. Robust expression in neural systems associated with cognitive, motor and sensory functions is consistent with the myriad of symptoms experienced by patients with triple A syndrome.