FKBP15 antibody (N-Term)

Catalog No. ABIN499840

This Rabbit Polyclonal antibody specifically detects FKBP15 in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FKBP15 antibody (N-Term) (ABIN499840)

Target: FKBP15 (FK506 Binding Protein 15, 133kDa (FKBP15))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP15 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-FKBP15 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to FKBP15.

Purification: Affinity chromatography purified via peptide column

Immunogen: FKBP15 antibody was raised against a 15 amino acid peptide from near the amino terminus of human FKBP15.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for FKBP15

Target: FKBP15 (FK506 Binding Protein 15, 133kDa (FKBP15))

Alternative Name: FKBP15

Background: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons, overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.Synonyms: 133 kDa FK506-binding protein, FK506-binding protein 15, FKBP133, KIAA0674, WAFL, WASP and FKBP-like

Gene ID: 23307

NCBI Accession: NP_056073

UniProt: Q5T1M5

Pathways: SARS-CoV-2 Protein Interactome