C9 antibody (AA 161-260) (Alexa Fluor 750)

Catalog No. ABIN4998744

Product Details anti-C9 Antibody (Alexa Fluor 750)

Target: C9 (Complement Component C9 (C9))

Binding Specificity: AA 161-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9 antibody is conjugated to Alexa Fluor 750

Application: Western Blotting (WB), Flow Cytometry (FACS)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement component C9a

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for C9

Target: C9 (Complement Component C9 (C9))

Alternative Name: C9a/C9 (C9 Products)

Synonyms: LOC100037951 antibody, LOC100136130 antibody, c9 antibody, wu:fb60b05 antibody, wu:fd50e04 antibody, zgc:112272 antibody, complement C9 antibody, complement component 9 antibody, complement component 9 L homeolog antibody, C9 antibody, c9 antibody, c9.L antibody

Background:

Synonyms: C9a, C9 deficiency, C9 deficiency with dermatomyositis, CO9_HUMAN, Complement component 9, Complement component 9 deficiency, Complement component C9a, Complement component C9a, C9.

Background: C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 Molecules. These polymerized C9 Molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

Pathways: Complement System