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ITGA4 antibody (Integrin alpha 4) (Center) Primary Antibody

ITGA4 Reactivity: Human, Mouse, Rat EIA, IF, WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN500032
$511.50
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
  • Target
    ITGA4
    Binding Specificity
    • 16
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 149
    • 116
    • 54
    • 19
    • 11
    • 9
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 74
    • 69
    • 65
    • 1
    • 1
    Rabbit
    Clonality
    • 144
    • 66
    • 1
    Polyclonal
    Conjugate
    • 98
    • 25
    • 25
    • 15
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA4 antibody is un-conjugated
    Application
    • 148
    • 51
    • 47
    • 45
    • 35
    • 23
    • 23
    • 13
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    This antibody reacts to Integrin alpha 4.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Integrin alpha 4 antibody was raised against a 15 amino acid peptide from near the center of human Integrin alpha 4.
    Isotype
    IgG
  • Application Notes
    ELISA. Western Blot: 0.5 - 1 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Gąciarz, Ruddock: "Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv." in: PLoS ONE, Vol. 12, Issue 12, pp. e0189964, 2018 (PubMed).

  • Target
    ITGA4
    Alternative Name
    CD49d / ITGA4 (ITGA4 Antibody Abstract)
    Synonyms
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Background
    The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha 4 beta 1 and alpha 4 beta 7 is located on the alpha 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha 4 beta 7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha 4 beta 7, the gut mucosal homing receptor for peripheral T cells. Despite its predicted molecular weight, Integrin alpha 4 will often run at higher molecular weight in SDS-PAGE. At least two isoforms are known to exist. The immunogen to this antibody is within the Integrin alpha 4 recombinant protein fragment and thus will recognize it.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
    Gene ID
    3676
    UniProt
    P13612
    Pathways
    Integrin Complex
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