IL28RA antibody (AA 51-150) (AbBy Fluor® 750)

Catalog No. ABIN5005330

The Rabbit Polyclonal anti-IL28RA antibody is suitable to detect IL28RA in samples from Human. It has been validated for WB, IF (cc) and IF (p).

Quick Overview for IL28RA antibody (AA 51-150) (AbBy Fluor® 750) (ABIN5005330)

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL28RA antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-IL28RA Antibody (AbBy Fluor® 750)

Binding Specificity: AA 51-150

Specificity: Predicted to also work in Rat based on sequence similarity

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-28R

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IL28RA

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Alternative Name: IL-28R

Background:

Synonyms: IFNLR, LICR2, IL28RA, CRF2/12, IL-28R1, Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, IFNLR1

Background: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gene ID: 163702

UniProt: Q8IU57