Integrin Alpha2b antibody (AA 351-450) (AbBy Fluor® 750)

Catalog No. ABIN5005465

The Rabbit Polyclonal anti-Integrin Alpha2b antibody has been validated for FACS, WB, IF (p) and IF (cc). It is suitable to detect Integrin Alpha2b in samples from Human and Rat.

Quick Overview for Integrin Alpha2b antibody (AA 351-450) (AbBy Fluor® 750) (ABIN5005465)

Target: Integrin Alpha2b (CD41)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to AbBy Fluor® 750

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-Integrin Alpha2b Antibody (AbBy Fluor® 750)

Binding Specificity: AA 351-450

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: Integrin alpha 2b/CD41

Background:

Synonyms: CD41, CD41B, GpIIb, AI172977, alphaIIb, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, Itga2b

Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Gene ID: 16399

UniProt: Q9QUM0

Pathways: Integrin Complex